04/04/2025 When it comes to Cardiovascular Health Supplements, not all ingredients are created equal—especially when we're talking about nattokinase, the enzyme extracted from the traditional Japanese food natto. Among all nattokinase options available today, NSK-SD® stands alone as the only form that has been extensively studied in human clinical trials. But why does that matter, and what makes NSK-SD® so unique? Let’s dive into the science, the safety, and the story behind this clinically validated enzyme.
What Is Nattokinase?
Nattokinase is a powerful enzyme produced during the fermentation of soybeans with Bacillus subtilis natto. For centuries, natto has been a staple in Japanese diets and has been associated with cardiovascular health benefits. The enzyme nattokinase gained attention for its ability to support healthy blood flow, help reduce fibrin (a protein involved in blood clot formation), and assist with overall circulation.
The Problem with Generic Nattokinase
While nattokinase supplements have surged in popularity, many generic versions lack rigorous quality control, clinical research, or even consistent enzyme activity. Without standardized manufacturing processes, these versions may have variable potency—or worse—may contain harmful residues from the fermentation process, such as vitamin K2 or bacterial contaminants.
This is where NSK-SD® distinguishes itself.
What Makes NSK-SD® Unique?
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Clinically Studied in Humans: NSK-SD® is the only form of nattokinase that has undergone peer-reviewed, placebo-controlled human clinical trials. These studies confirm its safety, effectiveness, and optimal dosage for supporting cardiovascular health. No other nattokinase product on the market can make this claim.
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Vitamin K2 Removed: Unlike raw natto or some unrefined nattokinase supplements, NSK-SD® is carefully processed to remove vitamin K2, which can interfere with certain blood-thinning medications. This makes it a safer option for those concerned about interactions.
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Purity and Safety: Manufactured by Japan Bio Science Laboratory (JBSL), NSK-SD® follows strict quality standards including ISO and GMP certifications. Each batch is tested for contaminants, potency, and enzyme activity to ensure consistent and reliable results.
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Backed by Science, Trusted by Doctors: Multiple published studies have shown that NSK-SD® helps reduce blood pressure, supports healthy circulation, and may assist in reducing the risk of blood clots. Because of this, it is often recommended by healthcare professionals as a natural option for cardiovascular support.
Clinical trials are the gold standard for evaluating a supplement’s safety and efficacy in humans. By using NSK-SD® in these studies, researchers can provide hard data on its effects—something other nattokinase products simply don’t have. This level of validation gives users peace of mind and ensures that they’re getting a supplement that works, not just one that “might.”
Choosing the Right Supplement
If you're considering nattokinase for cardiovascular support, choosing a supplement made with NSK-SD® is the smart choice. It's not just about having nattokinase—it's about having the right nattokinase, one that’s proven, purified, and powerful.
Where to Find NSK-SD®
You can find this clinically researched form of nattokinase in Nutrient Revolution’s high-quality supplement:
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